Pancreatic cancer seemed ‘undruggable,’ then scientists cracked a key target

For decades, one of the deadliest cancers had an Achilles’ heel lying in plain sight. Pancreatic cancer is an exquisitely cruel diagnosis, leaving only 13 percent of people alive after five years. But in the early 1980s, scientists discovered a weakness — a mutated protein called KRAS — that spurre...

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